Sodium cromoglycate and eformoterol attenuate sensitivity and reactivity to inhaled mannitol in subjects with bronchiectasis.

Abstract

BACKGROUND AND OBJECTIVE:

Dry powder mannitol has the potential to be used to enhance clearance of mucus in subjects with bronchiectasis. A reduction in FEV1 has been recorded in some subjects with bronchiectasis after inhaling mannitol. The aim of this study was to investigate if pre-medicating with either sodium cromoglycate (SCG) or eformoterol could inhibit this reduction in FEV1.

METHODS:

A double-blind, placebo-controlled, randomized cross-over study was conducted. Lung function and airway response to mannitol was assessed on a control day and then re-assessed after pre-medication with placebo, SCG and eformoterol in nine subjects. Sensitivity to mannitol, expressed as the dose required to induce a 15% fall in FEV1 (PD15), and reactivity to mannitol, expressed as the % fall in FEV1 per mg of mannitol (response-dose ratio, RDR), are reported.

RESULTS:

Subjects had an FEV1 of 68 ± 14% predicted, FVC of 97 ± 15% predicted and FEV1 /FVC of 71 ± 8%. They were mildly hypoxemic and the SpO2 was 95 ± 2%.They had a PD15 to mannitol of 235 mg (95% CI: 150-368 mg) and a RDR of 0.057% fall in FEV1 per mg (95% CI: 0.038-0.085). After pre-medication with SCG, PD15 increased (773 mg, P < 0.05) and RDR was reduced (0.013, P < 0.05). Pre-medication with eformoterol also resulted in an increased PD15 (1141 mg, P < 0.01) and a reduced RDR (0.009, P < 0.01). A small but significant decrease in SpO2 from baseline was noted after mannitol in the presence of SCG (P < 0.05).

CONCLUSIONS:

  Pre-medication with either SCG or eformoterol protects patients with bronchiectasis from developing a significant reduction in FEV1 after inhaling mannitol.

• Authors: Peter J Briffa, Sandra D Anderson, Deborah L Burton, Iven H Young
• Journal: Respirology (Carlton, Vic.) (Respirology) Vol. 16 Issue 1 Pg. 161-6 (Jan 2011) ISSN: 1440-1843 [Electronic] Australia
• PMID: 21054671 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2010 The Authors. Respirology © 2010 Asian Pacific Society of Respirology.

Chemical References

• Anti-Asthmatic Agents
• Ethanolamines
• Mannitol
• Cromolyn Sodium
• Oxygen
• Formoterol Fumarate

Topics

• Administration, Inhalation
• Adult
• Aged
• Anti-Asthmatic Agents (therapeutic use)
• Bronchial Provocation Tests
• Bronchiectasis (drug therapy)
• Cromolyn Sodium (therapeutic use)
• Cross-Over Studies
• Ethanolamines (therapeutic use)
• Female
• Forced Expiratory Volume (drug effects)
• Formoterol Fumarate
• Humans
• Male
• Mannitol (adverse effects, therapeutic use)
• Middle Aged
• Oxygen (blood)