Aplidiopsamine A, an antiplasmodial alkaloid from the temperate Australian ascidian, Aplidiopsis confluata.

Abstract

A polyaromatic alkaloid, aplidiopsamine A was isolated from the temperate Australian ascidian, Aplidiopsis confluata, and its structure was determined from interpretation of mass, 1D and 2D NMR spectra. Aplidiopsamine A is the first alkaloid to possess the tricyclic aromatic substructure 3H-pyrrolo[2,3-c]quinoline conjugated to an adenine. Aplidiopsamine A exhibited significant inhibition of growth of chloroquine resistant and sensitive strains of the malaria parasite, Plasmodium falciparum, and minimal toxicity toward human cells.

• Authors: Anthony R Carroll, Sandra Duffy, Vicky M Avery
• Journal: The Journal of organic chemistry (J Org Chem) Vol. 75 Issue 23 Pg. 8291-4 (Dec 03 2010) ISSN: 1520-6904 [Electronic] United States
• PMID: 21043526 (Publication Type: Journal Article)

Chemical References

• Alkaloids
• Antimalarials
• Plant Extracts
• Pyrroles
• Quinolines
• aplidiopsamine A

Topics

• Alkaloids (chemistry, isolation & purification, pharmacology)
• Animals
• Antimalarials (chemistry, isolation & purification, pharmacology)
• Australia
• Humans
• Magnetic Resonance Spectroscopy
• Models, Molecular
• Molecular Structure
• Plant Extracts (chemistry, pharmacology)
• Plasmodium falciparum (drug effects, isolation & purification)
• Pyrroles
• Quinolines