Successful use of quinine in the treatment of electrical storm in a child with Brugada syndrome.

Abstract

A 10-year-old girl developed life-threatening recurrent polymorphic ventricular tachycardia following surgical closure of a simple secundum atrial septal defect. Post hoc analysis of a Holter recording suggested Brugada syndrome. After managing the acute phase, a dual chamber defibrillator was implanted. One week later she experienced VF storm, needing 96 appropriate shocks within a few hours. Quinidine, by virtue of its I(to) blocking property, is the only drug reported to be useful in managing VF storm in Brugada syndrome. Nonavailability of quinidine led us to try its diastereomer, intravenous quinine, which succeeded in controlling the ventricular tachycardia. Arrhythmia storm in the setting of ion channelopathy can be difficult to manage, and sometimes requires innovative therapies.

• Authors: Sameer Mehrotra, Rajnish Juneja, Nitish Naik, Behzad B Pavri
• Journal: Journal of cardiovascular electrophysiology (J Cardiovasc Electrophysiol) Vol. 22 Issue 5 Pg. 594-7 (May 2011) ISSN: 1540-8167 [Electronic] United States
• PMID: 21040093 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2010 Wiley Periodicals, Inc.

Chemical References

• Muscle Relaxants, Central
• Quinine

Topics

• Brugada Syndrome (complications, surgery)
• Child
• Female
• Heart Septal Defects, Atrial (complications, surgery)
• Humans
• Muscle Relaxants, Central (therapeutic use)
• Quinine (therapeutic use)
• Tachycardia, Ventricular (drug therapy, etiology)
• Treatment Outcome