Abstract | OBJECTIVE: DATA SOURCES: English-language literature published and cited in MEDLINE from January 1966 to May 2009 was searched with the terms antipsychotic, atypical antipsychotic, generic and brand names of atypical antipsychotics, safety, tolerability, discontinuation due to adverse events, somnolence, sedation, weight gain, akathisia, or extrapyramidal side effect; and bipolar depression, major depressive disorder, or generalized anxiety disorder; and randomized, placebo-controlled clinical trial. This search was augmented with a manual search. STUDY SELECTION: Studies with a cumulative sample of ≥ 100 patients were included. DATA EXTRACTION: The NNTHs for discontinuation due to adverse events, somnolence, sedation, ≥ 7% weight gain, and akathisia relative to placebo were estimated with 95% confidence intervals to reflect the magnitude of variance. DATA SYNTHESIS: CONCLUSIONS: At the same dose of quetiapine-XR, patients with GAD appeared to have a lower tolerability than those with bipolar depression or MDD. Due to flexible dosing, the risk for discontinuation due to adverse events in the treatment of bipolar depression, MDD, or GAD with other atypical antipsychotics could not be compared.
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Authors | Keming Gao, David E Kemp, Elizabeth Fein, Zuowei Wang, Yiru Fang, Stephen J Ganocy, Joseph R Calabrese |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 72
Issue 8
Pg. 1063-71
(Aug 2011)
ISSN: 1555-2101 [Electronic] United States |
PMID | 21034695
(Publication Type: Case Reports, Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © Copyright 2011 Physicians Postgraduate Press, Inc. |
Chemical References |
- Antipsychotic Agents
- Delayed-Action Preparations
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Topics |
- Adverse Drug Reaction Reporting Systems
- Akathisia, Drug-Induced
(etiology)
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Anxiety Disorders
(diagnosis, drug therapy, psychology)
- Basal Ganglia Diseases
(chemically induced)
- Bipolar Disorder
(diagnosis, drug therapy, psychology)
- Delayed-Action Preparations
- Depressive Disorder, Major
(diagnosis, drug therapy, psychology)
- Disorders of Excessive Somnolence
(chemically induced)
- Dose-Response Relationship, Drug
- Drug Substitution
- Humans
- Product Surveillance, Postmarketing
- Randomized Controlled Trials as Topic
- Risk Factors
- Wakefulness
(drug effects)
- Weight Gain
(drug effects)
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