The effectiveness of a magnetic nanoparticle-based delivery system for BCNU in the treatment of gliomas.

Abstract

This study describes the creation and characterization of drug carriers prepared using the polymer poly[aniline-co-N-(1-one-butyric acid) aniline] (SPAnH) coated on Fe(3)O(4) cores to form three types of magnetic nanoparticles (MNPs); these particles were used to enhance the therapeutic capacity and improve the thermal stability of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a compound used to treat brain tumors. The average hydrodynamic diameter of the MNPs was 89.2 ± 8.5 nm and all the MNPs displayed superparamagnetic properties. A maximum effective dose of 379.34 μg BCNU could be immobilized on 1 mg of MNP-3 (bound-BCNU-3). Bound-BCNU-3 was more stable than free-BCNU when stored at 4 °C, 25 °C or 37 °C. Bound-BCNU-3 could be concentrated at targeted sites in vitro and in vivo using an externally applied magnet. When applied to brain tumors, magnetic targeting increased the concentration and retention of bound-BCNU-3. This drug delivery system promises to provide more effective tumor treatment using lower therapeutic doses and potentially reducing the side effects of chemotherapy.

• Authors: Mu-Yi Hua, Hao-Li Liu, Hung-Wei Yang, Pin-Yuan Chen, Rung-Ywan Tsai, Chiung-Yin Huang, I-Chou Tseng, Lee-Ang Lyu, Chih-Chun Ma, Hsiang-Jun Tang, Tzu-Chen Yen, Kuo-Chen Wei
• Journal: Biomaterials (Biomaterials) Vol. 32 Issue 2 Pg. 516-27 (Jan 2011) ISSN: 1878-5905 [Electronic] Netherlands
• PMID: 21030073 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents, Alkylating
• Carmustine

Topics

• Animals
• Antineoplastic Agents, Alkylating (administration & dosage, chemistry, therapeutic use)
• Carmustine (administration & dosage, chemistry, therapeutic use)
• Cell Line
• Cell Line, Tumor
• Drug Delivery Systems (methods)
• Glioma (drug therapy, pathology, ultrastructure)
• Humans
• Magnetic Resonance Imaging
• Male
• Microscopy, Electron, Transmission
• Nanoparticles (chemistry)
• Rats
• Rats, Sprague-Dawley