[A pilot study of weekly versus 3-week docetaxel in combination with capecitabine in patients with anthracycline-pretreated metastatic breast cancer].

Abstract

OBJECTIVE:

To evaluate the efficacy and safety of weekly or 3-week docetaxel in combination with capecitabine.

METHODS:

83 Patients with at least one measurable lesion were randomized to receive the treatment arms: docetaxel 37.5 mg/m(2) on days 1 and 8, oral capecitabine 950 mg/m(2) twice daily on days 1-14 (Group A); docetaxel 75 mg/m(2) on days 1, oral capecitabine 950 mg/m(2) twice daily on days 1-14 (Group B). Each cycle was repeated every 3 weeks.

RESULTS:

Eighty-three patients were enrolled, 78 eligible for tumor assessment. The overall clinical response rate of all groups was 61.4% (51/83). There was no progressive disease (PD) after two cycles. Efficacy outcomes were similar in the two groups. The response rate of group A and B were 61.8% (21/34) and 61.2% (30/49) respectively. There were no drug-related deaths observed. Neutropenia was the most common toxicity. In all, the frequency of Grade 3/4 neutropenia were 45.8% (38/83), but Grade 3/4 neutropenia of Group B 55.1% (27/49) was higher than Group A 32.4% (11/34), P = 0.04.

CONCLUSION:

The study confirmed the superior activity of docetaxe-capecitabine combination therapy in anthracycline resistant MBC, and comparing with 3-week schedule, weekly docetaxel plus capecitabine has same high efficacy with a favourable safety profile.

• Authors: Shao-hua Zhang, Ze-fei Jiang, Xiao-dong Xie, Yan Wei, Jun Ren, Ji-wei Liu, Wen-chao Liu, Xia Li, Yu-xian Bai, Shun-chang Jiao, Qiang Sun, Duan-qi Liu, Ju-xiang Xiao, Hua-qing Wang, Li-li Tang, Ying Cheng, Yu Wang, Yong-sheng Wang
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 90 Issue 26 Pg. 1813-5 (Jul 13 2010) ISSN: 0376-2491 [Print] China
• PMID: 20979824 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anthracyclines
• Taxoids
• Deoxycytidine
• Docetaxel
• Capecitabine
• Fluorouracil

Topics

• Adult
• Aged
• Anthracyclines (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Breast Neoplasms (drug therapy, secondary)
• Capecitabine
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Docetaxel
• Female
• Fluorouracil (administration & dosage, analogs & derivatives)
• Humans
• Middle Aged
• Neoplasm Recurrence, Local (drug therapy)
• Pilot Projects
• Taxoids (administration & dosage)
• Treatment Failure
• Treatment Outcome