Abstract | OBJECTIVE: SUBJECTS: Male C57BL/6 mice. TREATMENT: METHODS: RESULTS: K. pneumoniae was detectable in the blood and the liver at 12 h after infection. Liver abscess formation was visible earliest at 24 h after infection and most pronounced within the right liver lobes. ALP and ALT levels peaked at 12 and 24 h after infection, respectively. MPO was elevated in the right and left liver lobes at 12 h but only in the right lobes at 48 h after infection, compared to tissue levels in naïve mice. Liver IL-10 concentrations were not significantly increased. CONCLUSION:
Peritonitis led to liver injury and abscess formation but did not significantly affect tissue concentrations of anti-inflammatory IL-10.
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Authors | Andreas M Lenz, Mark Fairweather, James C Peyton, Sarah A Gardner, William G Cheadle |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 60
Issue 4
Pg. 337-45
(Apr 2011)
ISSN: 1420-908X [Electronic] Switzerland |
PMID | 20976524
(Publication Type: Journal Article)
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Chemical References |
- Interleukin-10
- Peroxidase
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Topics |
- Animals
- Bacterial Infections
(blood, complications, immunology, pathology)
- Humans
- Interleukin-10
(immunology)
- Klebsiella pneumoniae
(immunology, pathogenicity)
- Liver
(enzymology, immunology, injuries, pathology)
- Liver Abscess
(etiology, immunology, microbiology, pathology)
- Male
- Mice
- Mice, Inbred C57BL
- Peritonitis
(complications, immunology, microbiology)
- Peroxidase
(metabolism)
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