Abstract |
Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus (VSV) or human immunodeficiency virus type 1 (HIV-1). Adoptive transfer of virus-sensitized NK cells into naive recipient mice enhanced the survival of the mice after lethal challenge with the sensitizing virus but not after lethal challenge with a different virus. NK cell memory of haptens and viruses depended on CXCR6, a chemokine receptor on hepatic NK cells that was required for the persistence of memory NK cells but not for antigen recognition. Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell-expressed CXCR6.
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Authors | Silke Paust, Harvinder S Gill, Bao-Zhong Wang, Michael P Flynn, E Ashley Moseman, Balimkiz Senman, Marian Szczepanik, Amalio Telenti, Philip W Askenase, Richard W Compans, Ulrich H von Andrian |
Journal | Nature immunology
(Nat Immunol)
Vol. 11
Issue 12
Pg. 1127-35
(Dec 2010)
ISSN: 1529-2916 [Electronic] United States |
PMID | 20972432
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cxcr6 protein, mouse
- Haptens
- Receptors, CXCR
- Receptors, CXCR6
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Topics |
- Adaptive Immunity
(immunology)
- Adoptive Transfer
- Animals
- Cell Separation
- Chemotaxis, Leukocyte
(immunology)
- Cytotoxicity, Immunologic
(immunology)
- Flow Cytometry
- Haptens
(immunology)
- Immunologic Memory
(immunology)
- Killer Cells, Natural
(immunology, metabolism)
- Liver
(cytology, immunology)
- Lymphocyte Subsets
(immunology, metabolism)
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Receptors, CXCR
(immunology, metabolism)
- Receptors, CXCR6
- Virus Diseases
(immunology)
- Viruses
(immunology)
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