What is the significance of soluble and endogenous secretory receptor for advanced glycation end products in liver steatosis in obese prepubertal children?

Abstract

The endogenous secretory receptor for advanced glycation end products (esRAGE) and soluble RAGE (sRAGE) have been shown in human plasma and have emerged as reliable biomarkers of several pathological conditions, including insulin resistance and liver injury. We examined esRAGE and sRAGE levels in obese prepubertal children with and without liver steatosis. esRAGE and sRAGE levels were significantly lower in obese prepubertal children affected by liver steatosis and were independently related to liver steatosis. These findings suggest that AGE-RAGE pathway plays an independent role in the development of liver injury already present in this age group.

• Authors: Ebe D'Adamo, Cosimo Giannini, Valentina Chiavaroli, Tommaso de Giorgis, Alberto Verrotti, Francesco Chiarelli, Angelika Mohn
• Journal: Antioxidants & redox signaling (Antioxid Redox Signal) Vol. 14 Issue 6 Pg. 1167-72 (Mar 15 2011) ISSN: 1557-7716 [Electronic] United States
• PMID: 20969485 (Publication Type: Journal Article, Review)

Chemical References

• Receptor for Advanced Glycation End Products
• Receptors, Immunologic

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Fatty Liver (blood)
• Female
• Humans
• Male
• Obesity (blood)
• Receptor for Advanced Glycation End Products
• Receptors, Immunologic (blood)
• Young Adult