[Clinical significance of apolipoprotein B-48 (apoB-48) in chronic kidney disease patients].

Abstract

OBJECTIVES:

Apolipoprotein B-48 (apoB-48) is a constituent of chylomicrons and their remnants, and high levels of serum apoB-48 are thought to be one of the risk factors for atherosclerosis. In the current study we examined whether serum apoB-48 level is associated with renal dysfunction.

METHODS AND RESULTS:

Patients were separated by eGFR into each stage of chronic kidney disease (CKD). Serum apoB-48 levels were measured by chemiluminescence enzyme immunoassay (CLEIA), and serum lipid levels were compared between each stage of CKD. Serum triglyceride (TG) levels were high at stage 4 and stage 5. Serum total cholesterol, HDL-cholesterol (HDL-C), and LDL-cholesterol (LDL-C) levels were not significantly different. Serum apoB-48 level was significantly higher at stage 4 (Median: 8.3 microg/ml) and stage 5 (9.7 microg/ml) than at stage 1(4.2 microg/ml). Serum apoB-48 levels (10.7 microg/ml) in patients undergoing hemodialysis were not significantly higher than CKD patient of nondialysis (6.9 microg/ml).

CONCLUSION:

Serum apoB-48 level was strongly associated with renal dysfunction. Therefore, increased serum apoB-48 concentrations may contribute to the increased risk of atherosclerosis and coronary artery disease in the CKD patients.

• Authors: Manabu Okubo, Hiroyuki Hanada, Masahiko Matsui, Yoh Hidaka, Daisaku Masuda, Shizuya Yamashita
• Journal: Rinsho byori. The Japanese journal of clinical pathology (Rinsho Byori) Vol. 58 Issue 9 Pg. 878-83 (Sep 2010) ISSN: 0047-1860 [Print] Japan
• PMID: 20963947 (Publication Type: English Abstract, Journal Article)

Chemical References

• Apolipoprotein B-48

Topics

• Aged
• Apolipoprotein B-48 (blood)
• Chronic Disease
• Female
• Humans
• Kidney Diseases (blood)
• Kidney Failure, Chronic (blood)
• Male
• Middle Aged