Two-year clinical outcomes after large coronary stent (4.0 mm) placement: comparison of bare-metal stent versus drug-eluting stent.

Abstract

BACKGROUND:

The absolute benefit of drug-eluting stents (DES) in low-risk patients and lesions is not well established.

HYPOTHESIS:

The long term clinical outcomes after percutaneous coronary intervention in a single coronary artery disease may not be affected by the type of stent.

METHODS:

This study assessed and compared 2-year clinical outcomes of 304 consecutive patients (147 BMS patients and 157 DES patients) treated with a single coronary stent (4.0 mm) for single de novo large coronary artery disease in 3 referral cardiac centers. The primary outcome was a composite of major adverse cardiac events at 2 years after the index procedure.

RESULTS:

The reference vessel diameter was similar in both groups (3.92 ± 0.29 mm in BMS vs 3.95 ± 0.24 mm in DES, P = 0.50). Late loss was larger in the BMS group (1.04 ± 0.83 mm vs 0.73 ± 0.91 mm in DES, P = 0.03). The incidence of major adverse cardiac events at the 2-year clinical follow-up was very low, 24 of 304 patients (7.9%), regardless of stent type deployed (7.5% in BMS vs 8.3% in DES, P = 0.83). The rate of target vessel revascularization was also similar in both groups (4.8% in BMS vs 5.7% in DES, P = 0.80).

CONCLUSIONS:

Two-year clinical outcomes after PCI with a single large coronary stent (4.0 mm) were excellent. The clinical outcomes were not affected by the type of stent used.

• Authors: Hyun-Tae Kim, Chang-Wook Nam, Seung-Ho Hur, Kwon-Bae Kim, Sang-Hee Lee, Geu-Ru Hong, Jong-Seon Park, Young-Jo Kim, Ung Kim, Tae-Hyun Yang, Doo-Il Kim, Dong-Soo Kim
• Journal: Clinical cardiology (Clin Cardiol) Vol. 33 Issue 10 Pg. 620-625 (Oct 2010) ISSN: 1932-8737 [Electronic] United States
• PMID: 20960536 (Publication Type: Comparative Study, Journal Article, Multicenter Study)
• Copyright: © 2010 Wiley Periodicals, Inc.

Chemical References

• Tubulin Modulators
• zotarolimus
• Paclitaxel
• Sirolimus

Topics

• Coronary Angiography
• Coronary Stenosis (diagnostic imaging, surgery)
• Drug-Eluting Stents
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Paclitaxel (pharmacology)
• Postoperative Period
• Prosthesis Design
• Retrospective Studies
• Severity of Illness Index
• Sirolimus (analogs & derivatives, pharmacology)
• Time Factors
• Treatment Outcome
• Tubulin Modulators (pharmacology)