High levels of Crohn's disease-associated anti-microbial antibodies are present and independent of colitis in chronic granulomatous disease.

Abstract

Chronic granulomatous disease (CGD) and inflammatory bowel disease (IBD) have overlapping gastrointestinal manifestations. Serum antibodies to intestinal microbial antigens in IBD are thought to reflect a loss of tolerance in the setting of genetically encoded innate immune defects. CGD subjects studied here, with or without colitis, had considerably higher levels of ASCA IgA, ASCA IgG, anti-OmpC, anti-I2, and anti-CBir1, but absent to low pANCA, compared to IBD-predictive cutoffs. Higher antibody levels were not associated with a history of colitis. Except for higher ASCA IgG in subjects <18 years, antibody levels were not age-dependent. In comparison, 7 HIES subjects expressed negative to low antibody levels to all of these antigens; none had colitis. Our results suggest that markedly elevated levels of antimicrobial antibodies in CGD do not correlate with a history of colitis but may reflect a specific defect in innate immunity in the face of chronic antigenic stimulation.

• Authors: Joyce E Yu, Suk See De Ravin, Gulbu Uzel, Carol Landers, Stephan Targan, Harry L Malech, Steven M Holland, Wenqing Cao, Noam Harpaz, Lloyd Mayer, Charlotte Cunningham-Rundles
• Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 138 Issue 1 Pg. 14-22 (Jan 2011) ISSN: 1521-7035 [Electronic] United States
• PMID: 20956091 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural)
• Copyright: Copyright © 2010 Elsevier Inc. All rights reserved.

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Antibodies, Bacterial
• Antibodies, Fungal
• CBir1 flagellin
• OmpC protein
• Porins
• Flagellin

Topics

• Adolescent
• Adult
• Aging (blood, immunology)
• Antibodies, Antineutrophil Cytoplasmic (blood)
• Antibodies, Bacterial (blood, immunology)
• Antibodies, Fungal (blood, immunology)
• Child
• Child, Preschool
• Colitis (etiology, pathology)
• Crohn Disease (immunology)
• Female
• Flagellin (immunology)
• Granulomatous Disease, Chronic (blood, complications, diagnosis, genetics, immunology)
• Humans
• Immunity, Innate (immunology)
• Job Syndrome (blood, immunology)
• Male
• Middle Aged
• Porins (immunology)
• Pseudomonas fluorescens (immunology)
• Saccharomyces cerevisiae (immunology)
• Young Adult