Evaluation of Moon-tang on allergic reactions.

Abstract

Moon-tang (M-tang) is a traditional Korean medicine that has been used for the treatment of various allergic disorders. However, the precise antiallergic effect and mechanism of it remain unknown. To figure out accurately the effect of M-tang on mast cell-mediated allergic reactions, we measured parameters including changes in the compound 48/80-induced systemic anaphylaxis, ear-swelling response, histamine release, passive cutaneous anaphylaxis (PCA), and tumor necrosis factor (TNF)-α secretion and expression, which related to allergic inflammatory reaction. The oral administration of M-tang inhibited systemic anaphylaxis and ear-swelling response in mice. M-tang suppressed the PCA and histamine release. In addition, M-tang and its active component, β-eudesmol, inhibited the TNF-α production and expression in activated mast cells. These results suggest that M-tang may be a beneficial applicability as a candidate for an antiallergic agent.

• Authors: Na-Hyung Kim, In-Cheol Kang, Hyung-Min Kim, Hyun-Ja Jeong
• Journal: Immunopharmacology and immunotoxicology (Immunopharmacol Immunotoxicol) Vol. 33 Issue 2 Pg. 384-90 (Jun 2011) ISSN: 1532-2513 [Electronic] England
• PMID: 20946015 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Allergic Agents
• Plant Extracts

Topics

• Animals
• Anti-Allergic Agents (isolation & purification, pharmacology, therapeutic use)
• Drug Evaluation, Preclinical (methods)
• Edema (drug therapy, immunology)
• Humans
• Hypersensitivity (drug therapy, immunology)
• Male
• Mast Cells (drug effects, immunology)
• Medicine, Korean Traditional
• Mice
• Mice, Inbred ICR
• Passive Cutaneous Anaphylaxis (drug effects, immunology)
• Plant Extracts (isolation & purification, pharmacology, therapeutic use)
• Rats
• Rats, Sprague-Dawley