Interim clinical outcomes in the collaborative bleb-related infection incidence and treatment study.

Abstract

PURPOSE:

To introduce the Collaborative Bleb-related Infection Incidence and Treatment Study and to provide an interim, 2.5-year follow-up report of the findings. This prospective study sought to determine the incidence, severity, and prognosis of bleb-related infection and to investigate the efficacy of the antibacterial therapy in preventing it.

DESIGN:

Prospective cohort study.

PARTICIPANTS:

A total of 908 eyes of 908 glaucoma patients who had undergone mitomycin C-augmented trabeculectomy or trabeculectomy combined with phacoemulsification and intraocular lens implantation performed at 34 clinical centers.

METHODS:

Outcomes were measured at 6-month intervals, with special attention to bleb-related infections, and data for 2.5 years of follow-up result were summarized.

MAIN OUTCOME MEASURES:

The incidence and severity of bleb-related infection.

RESULTS:

Of the 908 eyes, 9 eyes developed a bleb-related infection. The Kaplan-Meier survival analysis revealed that the probability of development of bleb-related infection was 1.5±0.6% (cumulative probability ± standard error) at the 2.5-year follow in the trabeculectomy cases and 1.4±1.0% in the combined surgery cases. It was 1.5% in both cases with a limbal-based flap and in those with a fornix-based flap. It was significantly different between cases with bleb leakage and those without it (P = 0.037; log-rank test).

CONCLUSIONS:

The cumulative probability of bleb-related infection was prospectively determined to be 1.5±0.6% in eyes treated with mitomycin C-augmented trabeculectomy or trabeculectomy combined with phacoemulsification and intraocular lens implantation at the 2.5-year follow-up in the Collaborative Bleb-related Infection Incidence and Treatment Study.

• Authors: Tetsuya Yamamoto, Yasuaki Kuwayama, Collaborative Bleb-related Infection Incidence and Treatment Study Group
• Journal: Ophthalmology (Ophthalmology) Vol. 118 Issue 3 Pg. 453-8 (Mar 2011) ISSN: 1549-4713 [Electronic] United States
• PMID: 20932582 (Publication Type: Journal Article, Multicenter Study)
• Copyright: Copyright © 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Mitomycin

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (administration & dosage)
• Combined Modality Therapy
• Eye Infections, Bacterial (drug therapy, microbiology)
• Female
• Follow-Up Studies
• Glaucoma (surgery)
• Humans
• Incidence
• Intraocular Pressure (physiology)
• Lens Implantation, Intraocular
• Male
• Middle Aged
• Mitomycin (administration & dosage)
• Phacoemulsification
• Probability
• Prospective Studies
• Surgical Wound Infection (drug therapy, microbiology)
• Surgically-Created Structures (microbiology)
• Tonometry, Ocular
• Trabeculectomy
• Treatment Outcome
• Visual Acuity (physiology)
• Young Adult