The Ahmed Baerveldt Comparison Study methodology, baseline patient characteristics, and intraoperative complications.

Abstract

PURPOSE:

The Ahmed Baerveldt Comparison (ABC) Study compares the long-term outcomes and complications of the Ahmed glaucoma valve (AGV; model FP7; New World Medical, Los Ranchos, CA) and the Baerveldt glaucoma implant (BGI; model 101-350; Abbott Medical Optics, Abbott Park, IL).

DESIGN:

Multicenter, randomized, controlled clinical trial.

PARTICIPANTS:

Two hundred seventy-six glaucoma patients at 16 clinical centers worldwide who were 18 to 85 years of age with inadequately controlled intraocular pressure (IOP; ≥18 mmHg) in whom placement of an aqueous shunt was planned.

METHODS:

Study patients were randomized to undergo implantation of an AGV or a BGI.

MAIN OUTCOME MEASURES:

Failure, defined as IOP >21 mmHg or not reduced by 20% less than baseline or IOP ≤5 mmHg (2 consecutive visits after 3 months), additional glaucoma surgery, removal of the implant, or loss of light perception vision.

RESULTS:

A total of 276 patients were enrolled between October 2006 and April 2008, including 143 in the AGV group and 133 in the BGI group. The mean age±standard deviation (SD) of patients enrolled was 63±14 years, and 52% were male. The mean baseline IOP±SD was 31.5±11.8 mmHg. Except for a 13% higher prevalence of hypertension in the AGV group, no significant differences in baseline demographic or ocular characteristics were observed between the study groups. Intraoperative complications occurred in 11 (8%) patients in the AGV group and in 16 (12%) patients in the BGI group (P = 0.31).

CONCLUSIONS:

The ABC Study should yield valuable prospective data comparing 2 commonly used aqueous shunts in clinical practice.

• Authors: Keith Barton, Steven J Gedde, Donald L Budenz, William J Feuer, Joyce Schiffman, Ahmed Baerveldt Comparison Study Group
• Journal: Ophthalmology (Ophthalmology) Vol. 118 Issue 3 Pg. 435-42 (Mar 2011) ISSN: 1549-4713 [Electronic] United States
• PMID: 20932581 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Topics

• Adult
• Aged
• Aged, 80 and over
• Aqueous Humor (metabolism)
• Eye Movements (physiology)
• Female
• Follow-Up Studies
• Glaucoma (physiopathology, surgery)
• Glaucoma Drainage Implants
• Gonioscopy
• Humans
• Intraocular Pressure (physiology)
• Intraoperative Complications
• Male
• Middle Aged
• Prosthesis Implantation
• Refraction, Ocular (physiology)
• Tonometry, Ocular
• Treatment Outcome
• Visual Acuity (physiology)
• Visual Field Tests
• Young Adult