Primary intravitreal ranibizumab for adult-onset foveomacular vitelliform dystrophy.

Abstract

AIM:

To evaluate the efficacy of intravitreal injections of ranibizumab in adult-onset foveomacular vitelliform dystrophy (AOFVD).

METHODS:

Six female patients were misdiagnosed in the office as occult choroidal neovascularization due to AMD, and scheduled for 3-monthly intravitreal injections of ranibizumab. One month after the third injection, all patients underwent further examinations consisting of visual acuity, optical coherence tomography, Indocyanine Green angiography, electrophysiological tests (electroretinogram and electrooculogram), and an exhaustive familial history of macular diseases. Cases were followed-up every 6 weeks since the formal diagnose of AOFVD was evidenced.

RESULTS:

The mean BCVA improved from 0.36 ± 0.1 at baseline to 0.56 ± 0.1 (p = 0.038). No significant change was evidence in the SD-OCT thickness analysis. Metamorphopsia disappeared completely in all cases after the first injection. No familial history was evidenced.

CONCLUSIONS:

Ranibizumab intravitreal injections are effective in the short-term BCVA improvement in patients with AOFVD.

• Authors: Roberto Gallego-Pinazo, Rosa Dolz-Marco, Diamar Pardo-López, J Fernando Arevalo, Manuel Díaz-Llopis
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 249 Issue 3 Pg. 455-8 (Mar 2011) ISSN: 1435-702X [Electronic] Germany
• PMID: 20931215 (Publication Type: Case Reports, Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Coloring Agents
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Indocyanine Green
• Ranibizumab

Topics

• Aged
• Aged, 80 and over
• Angiogenesis Inhibitors (administration & dosage)
• Antibodies, Monoclonal (administration & dosage)
• Antibodies, Monoclonal, Humanized
• Coloring Agents
• Female
• Fluorescein Angiography
• Humans
• Indocyanine Green
• Intravitreal Injections
• Ranibizumab
• Tomography, Optical Coherence
• Treatment Outcome
• Vascular Endothelial Growth Factor A (antagonists & inhibitors)
• Visual Acuity (physiology)
• Vitelliform Macular Dystrophy (diagnosis, drug therapy, physiopathology)