Abstract | BACKGROUND AND OBJECTIVES: DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Plasma copeptin concentration (a marker of endogenous vasopressin levels) was measured in 102 ADPKD patients (diagnosis based on Ravine criteria) by an immunoassay. Plasma and urinary osmolarity were also measured. To assess disease severity, GFR and effective renal blood flow were measured by continuous infusion of 125I-iothalamate and 131I-hippuran, total renal volume by magnetic resonance imaging, and 24-hour urinary albumin excretion by nephelometry. RESULTS: In these ADPKD patients, copeptin was associated with the various markers of disease severity in ADPKD (positively with total renal volume [R=0.47] and albuminuria [R=0.39] and negatively with GFR [R=-0.58] and effective renal blood flow [R=-0.52], all P<0.001). These associations were independent of age, gender, and use of diuretics. Copeptin was furthermore associated with plasma osmolarity (P<0.001) but not with 24-hour urinary volume, 24-hour urinary osmolarity or fractional urea excretion (P=0.7, 0.9, and 0.3, respectively). CONCLUSIONS: On cross-sectional analysis, copeptin is associated with disease severity in ADPKD patients, supporting the results of experimental studies that suggest that vasopressin antagonists have a renoprotective effect in ADPKD and offering a good prospect for clinical studies with these agents.
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Authors | Esther Meijer, Stephan J L Bakker, Eric J van der Jagt, Gerjan Navis, Paul E de Jong, Joachim Struck, Ron T Gansevoort |
Journal | Clinical journal of the American Society of Nephrology : CJASN
(Clin J Am Soc Nephrol)
Vol. 6
Issue 2
Pg. 361-8
(Feb 2011)
ISSN: 1555-905X [Electronic] United States |
PMID | 20930090
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Glycopeptides
- Iodine Radioisotopes
- copeptins
- Vasopressins
- Iodohippuric Acid
- Iothalamic Acid
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Topics |
- Adult
- Albuminuria
(blood, diagnosis, physiopathology, urine)
- Biomarkers
(blood)
- Cross-Sectional Studies
- Female
- Glomerular Filtration Rate
- Glycopeptides
(blood)
- Humans
- Immunoassay
- Iodine Radioisotopes
- Iodohippuric Acid
- Iothalamic Acid
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Nephelometry and Turbidimetry
- Netherlands
- Osmolar Concentration
- Polycystic Kidney, Autosomal Dominant
(blood, diagnosis, physiopathology, urine)
- Predictive Value of Tests
- Regression Analysis
- Renal Blood Flow, Effective
- Severity of Illness Index
- Urodynamics
- Vasopressins
(blood)
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