Abstract | BACKGROUND: METHODS: VDR polymorphisms ( ApaI, TaqI, BsmI, FokI) were analyzed by standard methods from 29 Gaucher patients (some on enzyme therapy) with various cancers and from 70 healthy Ashkenazi Jews. Associations between VDR and categorical variables were analyzed by chi-square and Fisher's exact tests; associations with quantitative variables used ANOVA and Scheffe post-hoc tests. Non-parametric Kruskal-Wallis ANOVA was used when one category was small. IRB Committee approval was received for this study. FINDINGS: There was a trend for statistical significance (p=0.04) between patients and controls for the ApaI aa genotype. There were no correlations between VDR polymorphic genotypes and disease severity, need for ERT, splenectomy, or bone disease except a trend associating TaqI TT genotype with Zimran's severity score (p=0.06). CONCLUSION:
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Authors | Michelle Lieblich, Gheona Altarescu, Ari Zimran, Deborah Elstein |
Journal | Blood cells, molecules & diseases
(Blood Cells Mol Dis)
Vol. 46
Issue 1
Pg. 92-4
(Jan 15 2011)
ISSN: 1096-0961 [Electronic] United States |
PMID | 20920864
(Publication Type: Journal Article)
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Copyright | Copyright © 2010 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Female
- Gaucher Disease
(complications, genetics)
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Multiple Myeloma
(complications, genetics)
- Neoplasms
(complications, genetics)
- Polymorphism, Genetic
- Receptors, Calcitriol
(genetics)
- Severity of Illness Index
- Young Adult
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