[Hemorheological effects of thiophane on tetrachloromethane induced hepatic damage].

Abstract

Carbon tetrachloride-induced hepatitis in rats is accompanied by blood hyperviscosity syndrome development. A course intragastric administration of thiophane under these conditions prevents the increase in whole blood viscosity by normalizing the microrheological indices (deformability and aggregation of erythrocytes), which is manifested by increasing oxygen availability for tissues.

• Authors: V I Smol'iakova, M B Plotnikov, G A Chernysheva, I S Ivanov, A E Prosenko, N V Kandalintseva
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 73 Issue 8 Pg. 32-4 (Aug 2010) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 20919556 (Publication Type: Journal Article)

Chemical References

• Thiophenes
• thiophane
• Carbon Tetrachloride

Topics

• Animals
• Blood Viscosity (drug effects)
• Carbon Tetrachloride (toxicity)
• Carbon Tetrachloride Poisoning (blood)
• Chemical and Drug Induced Liver Injury (blood)
• Erythrocyte Aggregation (drug effects)
• Erythrocyte Deformability (drug effects)
• Male
• Rats
• Rats, Wistar
• Thiophenes (pharmacology)