[Electrophysiologic effects of penticainide in patients with supraventricular tachycardia].

Abstract

The electrophysiologic effects of the new class-I antiarrhythmic drug pentisomide were investigated after intravenous (5 mg/kg) application in nine patients with atrioventricular nodal reentrant tachycardia and six patients with atrioventricular tachycardia. Pentisomide did not change sinus cycle length, effective refractory period of the right ventricle (ERP-RV), the AV-node (ERP-AVN) and QT interval. Intranodal (AH-interval) and infranodal conduction time (HV-interval), effective refractory period of the right atrium (ERP-A), QRS duration, antegrade effective refractory period of the accessory pathway (ERP-Kent), ventricular cycle length during atrial fibrillation and tachycardia cycle length were significantly (P less than 0.05) increased. Intravenous pentisomide prevented induction of the tachycardia in 5/9 patients with atrioventricular nodal tachycardia and in 2/6 patients with atrioventricular tachycardia. The electrophysiologic properties of pentisomide indicate that it might be a useful drug in the treatment of supraventricular tachycardia.

• Authors: V Kühlkamp, C Mewis, F Mayer, L Seipel
• Journal: Zeitschrift fur Kardiologie (Z Kardiol) Vol. 79 Issue 10 Pg. 725-31 (Oct 1990) ISSN: 0300-5860 [Print] Germany
• Vernacular Title: Elektrophysiologische Effekte von Pentisomid bei Patienten mit supraventrikulärer Tachykardie.
• PMID: 2087860 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Propylamines
• Pyridines
• propisomide

Topics

• Adult
• Anti-Arrhythmia Agents
• Cardiac Pacing, Artificial
• Electrocardiography (drug effects)
• Female
• Heart Conduction System (drug effects)
• Humans
• Male
• Middle Aged
• Propylamines (administration & dosage)
• Pyridines
• Tachycardia, Atrioventricular Nodal Reentry (drug therapy)
• Tachycardia, Supraventricular (drug therapy)
• Wolff-Parkinson-White Syndrome (drug therapy)