Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy.

Abstract

Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition.

• Authors: Gregory A Dierksen, Maureen E Skehan, Muhammad A Khan, Jed Jeng, R N Kaveer Nandigam, John A Becker, Ashok Kumar, Krista L Neal, Rebecca A Betensky, Matthew P Frosch, Jonathan Rosand, Keith A Johnson, Anand Viswanathan, David H Salat, Steven M Greenberg
• Journal: Annals of neurology (Ann Neurol) Vol. 68 Issue 4 Pg. 545-8 (Oct 2010) ISSN: 1531-8249 [Electronic] United States
• PMID: 20865701 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
• Amyloid
• Aniline Compounds
• Thiazoles

Topics

• Aged
• Amyloid (metabolism)
• Aniline Compounds
• Cerebral Amyloid Angiopathy (complications, diagnostic imaging, metabolism, pathology)
• Female
• Humans
• Intracranial Hemorrhages (etiology)
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• Positron-Emission Tomography (methods)
• Thiazoles