New universal definition of myocardial infarction applicable after complex percutaneous coronary interventions?

Abstract

OBJECTIVES:

This study aimed to characterize myocardial infarction after percutaneous coronary intervention (PCI) based on cardiac marker elevation as recommended by the new universal definition and on the detection of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR). It is also assessed whether baseline inflammatory biomarkers are higher in patients developing myocardial injury.

BACKGROUND:

Cardiovascular magnetic resonance accurately assesses infarct size. Baseline C-reactive protein (CRP) and neopterin predict prognosis after stent implantation.

METHODS:

Consecutive patients with baseline troponin (Tn) I within normal limits and no LGE in the target vessel underwent baseline and post-PCI CMR. The Tn-I was measured until 24 h after PCI. Serum high-sensitivity CRP and neopterin were assessed before coronary angiography.

RESULTS:

Of 45 patients, 64 (53 to 72) years of age, 33% developed LGE with infarct size of 0.83 g (interquartile range: 0.32 to 1.30 g). A Tn-I elevation >99% upper reference limit (i.e., myocardial necrosis) (median Tn-I: 0.51 μg/l, interquartile range: 0.16 to 1.23) and Tn-I > 3× upper reference limit (i.e., type 4a myocardial infarction [MI]) occurred in 58% and 47% patients, respectively. LGE was undetectable in 42% and 43% of patients with periprocedural myocardial necrosis and type 4a MI, respectively. Agreement between LGE and type 4a MI was moderate (kappa = 0.45). The levels of CRP or neopterin did not significantly differ between patients with or without myocardial injury, detected by CMR or according to the new definition (p = NS).

CONCLUSIONS:

This study reports the lack of substantial agreement between the new universal definition and CMR for the diagnosis of small-size periprocedural myocardial damage after complex PCI. Baseline levels of CRP or neopterin were not predictive for the development of periprocedural myocardial damage.

• Authors: Didier Locca, Chiara Bucciarelli-Ducci, Giuseppe Ferrante, Alessio La Manna, Niall G Keenan, Agata Grasso, Peter Barlis, Francesca Del Furia, Sanjay K Prasad, Juan Carlos Kaski, Dudley J Pennell, Carlo Di Mario
• Journal: JACC. Cardiovascular interventions (JACC Cardiovasc Interv) Vol. 3 Issue 9 Pg. 950-8 (Sep 2010) ISSN: 1876-7605 [Electronic] United States
• PMID: 20850095 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Neopterin
• C-Reactive Protein

Topics

• Aged
• Angioplasty, Balloon, Coronary
• Biomarkers (blood)
• C-Reactive Protein (metabolism)
• Coronary Angiography (methods)
• Female
• Follow-Up Studies
• Humans
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• Myocardial Infarction (blood, diagnosis, therapy)
• Neopterin (blood)
• Prognosis
• Prospective Studies
• ROC Curve
• Treatment Outcome