Association of combinations of lipid parameters with carotid intima-media thickness and coronary artery calcium in the MESA (Multi-Ethnic Study of Atherosclerosis).
Abstract | OBJECTIVES: The purpose of this study was to determine the association of combinations of lipid parameters with subclinical atherosclerosis. BACKGROUND: METHODS: RESULTS: Among 4,792 participants, only those with combined hyperlipidemia and hypercholesterolemia demonstrated both increased common CIMT (combined hyperlipidemia 0.048 mm thicker, 95% confidence interval [CI]: 0.016 to 0.080 mm; hypercholesterolemia 0.048 mm thicker, 95% CI: 0.029 to 0.067 mm) and internal CIMT (combined hyperlipidemia 0.120 mm thicker, 95% CI: 0.032 to 0.208 mm; and hypercholesterolemia 0.161 mm thicker, 95% CI: 0.098 to 0.223 mm) as well as increased risk for prevalent CAC (combined hyperlipidemia relative risk: 1.22, 95% CI: 1.08 to 1.38; hypercholesterolemia relative risk: 1.22, 95% CI: 1.11 to 1.34) compared with normolipemia. The interactions between lipid parameters and race, sex, or high-sensitivity C-reactive protein were not significant for any outcomes. CONCLUSIONS:
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Authors | Pathmaja Paramsothy, Robert H Knopp, Alain G Bertoni, Roger S Blumenthal, Bruce A Wasserman, Michael Y Tsai, Tessa Rue, Nathan D Wong, Susan R Heckbert |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 56
Issue 13
Pg. 1034-41
(Sep 21 2010)
ISSN: 1558-3597 [Electronic] United States |
PMID | 20846602
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Lipids
- Triglycerides
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Topics |
- Aged
- Aged, 80 and over
- Calcinosis
(diagnostic imaging)
- Carotid Arteries
(diagnostic imaging)
- Carotid Artery Diseases
(blood, complications, diagnostic imaging, ethnology)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Coronary Artery Disease
(blood, complications, diagnostic imaging, ethnology)
- Dyslipidemias
(blood, complications)
- Female
- Humans
- Hypercholesterolemia
(blood, complications)
- Hyperlipidemia, Familial Combined
(blood, complications)
- Lipids
(blood)
- Male
- Middle Aged
- Prospective Studies
- Radiography
- Regression Analysis
- Risk
- Risk Factors
- Triglycerides
(blood)
- Tunica Intima
(diagnostic imaging)
- Tunica Media
(diagnostic imaging)
- Ultrasonography
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