Abstract | OBJECTIVE: To evaluate whether the renin-angiotensin-aldosterone system (RAAS) and endogenous ouabain system differently affect renal Na handling and blood pressure. METHODS: Three hundred and one patients in whom we compared blood pressure, and renal Na tubular reabsorption in the basal condition and 2 h (T120) after saline infusion. RESULTS: Following multivariate-adjusted linear and quartiles analysis, baseline mean blood pressure (MBP) was significantly higher (113.7 ± 1.33 mmHg) in the fourth versus the first endogenous ouabain quartile (103.8 ± 1.04 mmHg) and the trend across the quartiles was highly significant (β = 0.23, P = 3.53e-04). In contrast, an inverse relationship was present in the renin activity (PRA) quartiles with MBP highest in the first (112.5 ± 1.26) and lowest in the fourth PRA quartile (107.6 ± 1.48, P = 0.039). Following an acute saline load, changes in MBP and the slope of the pressure-natriuresis relationship were inversely related across the PRA quartiles. The fractional excretion of sodium (FENa) showed a negative linear trend going from the first to the third endogenous ouabain quartiles (2.35 ± 0.17 and 1.90 ± 0.14%, P = 0.05). Patients in the fourth endogenous ouabain quartile (>323 pmol/l) showed increased FENa T120 (2.78 ± 0.18%, P < 0.01) and increased Na tubular rejection fraction (P = 0.007) after Na load. After the saline load, there was a biphasic relationship between plasma endogenous ouabain and FENa favoring Na retention at low endogenous ouabain and Na excretion at high endogenous ouabain levels. CONCLUSION: The RAAS and endogenous ouabain system are two independent and complementary systems having an inverse (RAAS) or a direct (endogenous ouabain system) relationship with hemodynamic parameters.
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Authors | Paolo Manunta, John M Hamlyn, Marco Simonini, Elisabetta Messaggio, Chiara Lanzani, Maria Bracale, Giuseppe Argiolas, Nunzia Casamassima, Elena Brioni, Nicola Glorioso, Giuseppe Bianchi |
Journal | Journal of hypertension
(J Hypertens)
Vol. 29
Issue 2
Pg. 349-56
(Feb 2011)
ISSN: 1473-5598 [Electronic] Netherlands |
PMID | 20842047
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aldosterone
- Ouabain
- Sodium
- Renin
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Topics |
- Adult
- Aldosterone
(blood)
- Blood Pressure
(physiology)
- Female
- Humans
- Hypertension
(blood, physiopathology)
- Kidney Tubules
(physiopathology)
- Linear Models
- Male
- Middle Aged
- Natriuresis
(physiology)
- Ouabain
(blood)
- Renin
(blood)
- Renin-Angiotensin System
(physiology)
- Sodium
(blood, metabolism)
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