Abstract | OBJECTIVE: METHODS: Forty-two patients with newly diagnosed NSCLC underwent (18)F-FETNIM PET-CT before treatment. Nineteen patients rested for approximately 120 minutes before undergoing PET-CT, 23 patients underwent 2 sequential PET-CT scans at 60 minutes and 120 minutes after intravenous injection (18)F-FETNIM. (18)F-FETNIM uptake was quantified by calculating the maximum standardized uptake value in the tumor (SUVmax-T) and contralateral normal lung tissue (SUVmax-N). Regions of interest (ROIs) were drawn in the tumor and contralateral position and the radioactivity ratio of tumor to normal (T/N) was calculated. RESULTS: SUVmax-T (2.43 +/- 1.34) was significantly higher than SUVmax-N (0.87 +/- 0.46, P < 0.001) at 120 min. SUVmax-T (2.80 +/- 1.09) and SUVmax-N (1.16 +/- 0.56) at 60 min were significantly higher than SUVmax-T (2.61 +/- 1.10) and SUVmax-N (P < 0.01) at 120 min. T/N (2.56 +/- 0.71) at 60 min was higher than that at 120 min (2.48 +/- 0.60), but the difference between them was not significant (P = 0.324). CONCLUSION: Our results indicate that (18)F-FETNIM PET-CT may be a useful tool for evaluating hypoxia and may be a means to target specifically tumor cells resistant to conventional treatment before and during ongoing therapy in NSCLC.
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Authors | Man Hu, Li Kong, Shu-Qiang Zhao, Guo-Ren Yang, Wen-Feng Yang, An-Qin Han, Zheng Fu, Li Ma, Jin-Song Zheng, Jin-Ming Yu |
Journal | Zhonghua zhong liu za zhi [Chinese journal of oncology]
(Zhonghua Zhong Liu Za Zhi)
Vol. 32
Issue 6
Pg. 463-6
(Jun 2010)
ISSN: 0253-3766 [Print] China |
PMID | 20819492
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Nitroimidazoles
- fluoroerythronitroimidazole
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Non-Small-Cell Lung
(diagnostic imaging, pathology)
- Cell Hypoxia
- Female
- Humans
- Lung Neoplasms
(diagnostic imaging, pathology)
- Male
- Middle Aged
- Nitroimidazoles
- Positron-Emission Tomography
(methods)
- Tomography, X-Ray Computed
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