Abstract | PURPOSE: METHODS: RESULTS: CONCLUSIONS: These results demonstrate that NO is produced in our in vitro GA model, which induced cytotoxicity of RPE cells and upregulation of arginase II. NO may be involved in RPE degeneration in GA through the regulation of arginase II mRNA expression.
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Authors | Masayuki Ohnaka, Emiko Okuda-Ashitaka, Shiho Kaneko, Akira Ando, Masahide Maeda, Kyoji Furuta, Masaaki Suzuki, Kanji Takahashi, Seiji Ito |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 52
Issue 3
Pg. 1493-500
(Mar 18 2011)
ISSN: 1552-5783 [Electronic] United States |
PMID | 20811048
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- (2-boronoethyl)-cysteine
- Boronic Acids
- Enzyme Inhibitors
- RNA, Messenger
- Tetrazolium Salts
- Thiazoles
- 5-fluoromethylornithine
- Nitric Oxide
- Ornithine
- ARG2 protein, human
- Arginase
- thiazolyl blue
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Topics |
- Animals
- Arginase
(antagonists & inhibitors, genetics)
- Boronic Acids
(pharmacology)
- Cell Line
- Enzyme Inhibitors
(pharmacology)
- Gyrate Atrophy
(metabolism)
- Humans
- Models, Biological
- Nitric Oxide
(metabolism)
- Ornithine
(analogs & derivatives, pharmacology)
- RNA Interference
- RNA, Messenger
(biosynthesis)
- Retinal Pigment Epithelium
(drug effects, enzymology)
- Reverse Transcriptase Polymerase Chain Reaction
- Swine
- Tetrazolium Salts
(metabolism)
- Thiazoles
(metabolism)
- Up-Regulation
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