Abstract | OBJECTIVE: Genome-wide association studies (GWASs) identified that SLC30A8 genetic polymorphism was a risk of type 2 diabetes mellitus (T2DM) in several populations. This study aimed to investigate whether the SLC30A8 rs13266634 and rs16889462 polymorphisms were associated with T2DM susceptibility and repaglinide therapeutic efficacy in Chinese T2DM patients. METHODS: RESULTS: SLC30A8 rs13266634 risk C allele frequency was higher in T2DM patients than in healthy controls (P < 0.05). There was a better repaglinide response on FINS (P < 0.05) and PINS (P < 0.01) in patients with rs13266634 CT+TT genotypes compared with CC genotype carriers. Patients with rs16889462 GA genotype showed an enhanced repaglinide efficacy on FPG (P < 0.01), PPG (P < 0.01) and HbAlc (P < 0.05) compared with GG genotype individuals. CONCLUSIONS: SLC30A8 rs13266634 and rs16889462 polymorphisms were associated with repaglinide therapeutic efficacy in Chinese T2DM patients.
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Authors | Qiong Huang, Ji-Ye Yin, Xing-Ping Dai, Jing Wu, Xiang Chen, Cai-Shu Deng, Min Yu, Zhi-Cheng Gong, Hong-Hao Zhou, Zhao-Qian Liu |
Journal | European journal of clinical pharmacology
(Eur J Clin Pharmacol)
Vol. 66
Issue 12
Pg. 1207-15
(Dec 2010)
ISSN: 1432-1041 [Electronic] Germany |
PMID | 20809084
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carbamates
- Cation Transport Proteins
- DNA Primers
- Hypoglycemic Agents
- Piperidines
- SLC30A8 protein, human
- Zinc Transporter 8
- repaglinide
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Topics |
- Adult
- Aged
- Base Sequence
- Carbamates
(therapeutic use)
- Case-Control Studies
- Cation Transport Proteins
- China
- DNA Primers
- Diabetes Mellitus, Type 2
(genetics)
- Female
- Gene Frequency
- Genome-Wide Association Study
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Male
- Middle Aged
- Piperidines
(therapeutic use)
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Zinc Transporter 8
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