Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism.

Abstract

A 64-year-old Egyptian man who resides in the United States presented to the rheumatology clinic with 6 months history of episodic recurrent pauci--arthritis along with constitutional symptoms. His Mediterranean ancestry, anti-cyclic citrullinated peptide negativity, and cyclical palindromic rheumatism prompted an investigation for familial Mediterranean fever gene mutation. He was found to have heterozygous 694I gene mutation during MEFV analysis. He also met Liveneh 1 major and 1 minor criteria for the diagnosis of familial Mediterranean fever.

• Authors: Nirupa J Patel, Vijay R Karia, Abraham Gedalia, Luis R Espinoza
• Journal: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases (J Clin Rheumatol) Vol. 16 Issue 6 Pg. 290-2 (Sep 2010) ISSN: 1536-7355 [Electronic] United States
• PMID: 20808171 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Anti-Idiotypic
• Cytoskeletal Proteins
• MEFV protein, human
• Peptides, Cyclic
• Pyrin
• cyclic citrullinated peptide

Topics

• Antibodies, Anti-Idiotypic (metabolism)
• Arthritis, Rheumatoid (diagnosis, epidemiology, immunology)
• Comorbidity
• Cytoskeletal Proteins (genetics)
• Diagnosis, Differential
• Familial Mediterranean Fever (diagnosis, epidemiology, genetics)
• Humans
• Male
• Middle Aged
• Mutation (genetics)
• Peptides, Cyclic (immunology)
• Pyrin