Seventy-seven patients with primary malignant
testicular tumors were treated in our hospital. Twenty-five of them were given
antineoplastic agents containing cis
diamine dichloro
platinum (CDDP). In three long-term survivors, new malignant
testicular tumors developed meta-chronously and had different histological findings from those of the initial
tumors. Case 1. A 28-year-old patient with a
yolk sac tumor of the left testicle, stage IIO, developed
metastasis to the supraclavicular lymph nodes five years after radiation.
Chemotherapy containing of
VP-16 (837 mg), CDDP (1050 mg),
vincristine (32 mg),
bleomycin (480 mg), and
actinomycin-D (16 mg) achieved complete remission. Four years 11 months later a
seminoma of the contralateral testicle, stage I, was disclosed and he died of
cancer 11 years and four months after the onset of the initial disease. Case 2. A 30-year-old patient with
testicular teratoma, stage IIIA, on the right side gained complete remission after a CDDP containing
chemotherapy. One year and four months after the beginning of the CDDP use (1,300 mg totally as CDDP) a
seminoma on the contralateral side, stage I, was detected. He died of
cancer eight years and two months after his initial
tumor was detected. Case 3. A 37-year-old patient with combined
tumor of
seminoma and
yolk sac tumor of the right testicle, stage IIIO, was free from disease for six years and five months under
chemotherapy. At this point a
seminoma, stage I, of the contralateral testicle was newly found and treated by radiation.(ABSTRACT TRUNCATED AT 250 WORDS)