Defining a new paradigm for human arrhythmia syndromes: phenotypic manifestations of gene mutations in ion channel- and transporter-associated proteins.

Abstract

Over the past 15 years, gene mutations in cardiac ion channels have been linked to a host of potentially fatal human arrhythmias including long QT syndrome, short QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia. More recently, a new paradigm for human arrhythmia has emerged based on gene mutations that affect the activity of cardiac ion channel- and transporter- associated proteins. As part of the Circulation Research thematic series on inherited arrhythmias, this review focuses on the emerging field of human arrhythmias caused by dysfunction in cytosolic gene products (including ankyrins, yotiao, syntrophin, and caveolin-3) that regulate the activities of key membrane ion channels and transporters.

• Authors: Michael J Ackerman, Peter J Mohler
• Journal: Circulation research (Circ Res) Vol. 107 Issue 4 Pg. 457-65 (Aug 20 2010) ISSN: 1524-4571 [Electronic] United States
• PMID: 20724725 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Ion Channels
• Membrane Transport Proteins

Topics

• Animals
• Arrhythmias, Cardiac (genetics, metabolism)
• Humans
• Ion Channels (genetics, metabolism)
• Membrane Transport Proteins (genetics, metabolism)
• Mutation (genetics)
• Phenotype
• Syndrome