Abstract | INTRODUCTION: PATIENTS AND METHODS: RESULTS: From March 2005 to September 2006, 76 patients were enrolled. Of the 7 patients who were randomized to docetaxel alone, 6 crossed over to docetaxel/ bevacizumab (included in the safety analysis only). Two patients were found to be ineligible before receiving drug. Efficacy data are based on the 67 patients who were originally enrolled in the docetaxel/ bevacizumab arm and received at least 1 dose of study medication. The confirmed objective response rate is 51% (34 of 67) with 9% complete responses (6 of 67) and 42% partial responses (28 of 67). Nine additional patients (13%) had stable disease lasting >or= 6 months. With a median follow-up of 21.7 months, the median time to progression is 9.3 months, and median overall survival is 26.3 months. Common grade 3/4 adverse events included neutropenia (33%), leukopenia/ lymphopenia (25%), fatigue (22%), infection (17%), pain (16%), and hypertension (9%). CONCLUSION:
Docetaxel/ bevacizumab was generally well tolerated with manageable toxicity and promising efficacy results.
|
Authors | Sara A Hurvitz, Heather J Allen, Rebecca L Moroose, David Chan, Christopher Hagenstad, Steven H Applebaum, Giribala Patel, Eddie H Hu, Nancy Ryba, Lii-Shin Lin, Hejing Wang, John Glaspy, Dennis J Slamon, Fairooz Kabbinavar |
Journal | Clinical breast cancer
(Clin Breast Cancer)
Vol. 10
Issue 4
Pg. 307-12
(Aug 01 2010)
ISSN: 1938-0666 [Electronic] United States |
PMID | 20705564
(Publication Type: Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Taxoids
- Docetaxel
- Bevacizumab
- Receptor, ErbB-2
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Monoclonal
(administration & dosage, adverse effects)
- Antibodies, Monoclonal, Humanized
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bevacizumab
- Breast Neoplasms
(drug therapy, genetics, pathology)
- Cross-Over Studies
- Disease-Free Survival
- Docetaxel
- Female
- Humans
- Kaplan-Meier Estimate
- Middle Aged
- Neoplasm Staging
- Receptor, ErbB-2
(genetics)
- Taxoids
(administration & dosage, adverse effects)
|