Abstract | BACKGROUND: METHODS: RESULTS: The mean body mass index, Hb, and ferritin decreased after surgery. The body mass index decreased from 50.1 kg/m(2) (95% confidence interval [CI] 49.6-50.6) at baseline to 33.0 kg/m(2) (95% CI 32.3-33.6) at 12 months and remained unchanged thereafter. The Hb level decreased from 13.4 g/dL (95% CI 13.3-13.5) to 12.8 (95% CI 12.6-13.1) and ferritin from 87.5 ng/mL (95% CI 75.2-99.7) to 55.4 (95% CI 42.9-68.0) at 24-48 months, and serum iron increased from 68.4 μg/dL (95% CI 66.8-70.0) to 82.8 (95% CI 76.4-88.7); all P values were <.01. Anemia was present in 12% (95% CI 10-14%) of patients at baseline and had increased to 23% (95% CI 16-30%) at 24-48 months. The changes in ferritin, Hb, and the percentage of patients with anemia were most pronounced in premenopausal women. Vitamin B(12) and folate levels were unaffected. CONCLUSION: The baseline incidence of anemia was greater than expected and increased significantly after surgery. The percentage of those with anemia and low ferritin was most significant in premenopausal women; however, the overall iron bioavailability improved significantly with pronounced weight loss, suggesting a reduction in inflammation. These findings indicate that anemia after bariatric surgery cannot be explained on the basis of iron availability and suggest that other mechanisms, currently undefined, contribute to the development of anemia in these patients.
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Authors | Annette von Drygalski, Deborah A Andris, Peter R Nuttleman, Scott Jackson, John Klein, James R Wallace |
Journal | Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
(Surg Obes Relat Dis)
2011 Mar-Apr
Vol. 7
Issue 2
Pg. 151-6
ISSN: 1878-7533 [Electronic] United States |
PMID | 20702143
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2011 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Hemoglobins
- Ferritins
- Iron
- Vitamin B 12
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Topics |
- Adult
- Anemia
(blood, epidemiology, etiology)
- Anemia, Iron-Deficiency
(epidemiology, etiology)
- Bariatric Surgery
(adverse effects)
- Biomarkers
(blood)
- Body Mass Index
- Female
- Ferritins
(blood)
- Follow-Up Studies
- Hemoglobins
(metabolism)
- Humans
- Incidence
- Iron
(blood)
- Male
- Obesity, Morbid
(blood, surgery)
- Prognosis
- Prospective Studies
- Risk Factors
- Time Factors
- Vitamin B 12
(blood)
- Wisconsin
(epidemiology)
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