Dietary consumption of antioxidant nutrients and risk of incident cervical intraepithelial neoplasia.

Abstract

OBJECTIVE:

Women with human papillomavirus (HPV) infections are at risk for developing squamous intraepithelial lesions (SIL) of the cervix; however, other factors are required for infections to progress to SIL. We hypothesize that consumption of fruits and vegetables high in antioxidant nutrients may prevent, in part, the development of HPV-associated SIL.

METHODS:

This study is a nested case-control study of 265 HPV-positive women (93 SIL cases and 172 cytologically normal controls) in the Ludwig-McGill Cohort Study, São Paulo, Brazil. Diet was assessed by a self-administered food frequency questionnaire. The association between food and nutrient intake of antioxidants and incident SIL was determined by logistic regression and multinomial regression when comparing LSIL and HSILs.

RESULTS:

Higher reported consumption of papaya was inversely associated with risk of SIL (p trend=0.01) and strongest for >or=1 time/week (adjusted odds ratios (AORs)=0.19; 95%CI, 0.08-0.49). Risk of SIL was reduced among women reporting consumption of oranges >or=1 time/week (AOR=0.32; 95%CI, 0.12-0.87; p-trend=0.02). Nutrient intakes of ss-cryptoxanthin and alpha-carotene were marginally protective against SIL.

CONCLUSIONS:

Frequent consumption of fruits high in antioxidant nutrients appears to be associated with reduced risk of incident SIL among Brazilian women.

• Authors: Erin M Siegel, Jason L Salemi, Luisa L Villa, Alex Ferenczy, Eduardo L Franco, Anna R Giuliano
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 118 Issue 3 Pg. 289-94 (Sep 2010) ISSN: 1095-6859 [Electronic] United States
• PMID: 20691333 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 Elsevier Inc. All rights reserved.

Chemical References

• Antioxidants

Topics

• Adult
• Antioxidants (administration & dosage)
• Brazil (epidemiology)
• Case-Control Studies
• Cohort Studies
• Diet
• Female
• Fruit
• Humans
• Papillomavirus Infections (epidemiology, pathology)
• Uterine Cervical Neoplasms (epidemiology, prevention & control, virology)
• Vegetables
• Young Adult
• Uterine Cervical Dysplasia (epidemiology, prevention & control, virology)