Abstract | OBJECTIVE: METHODS: A total of 135 patients with asthenozoospermia were randomly divided into Groups A (n = 68) and B (n = 67), the former treated with L-carnitine (2 g/d) and vitamin E, while the latter with vitamin E only, both for 3 months. All the patients received semen analyses before and after the treatment, and were observed for adverse effects. The pregnancy rates of their wives were recorded. RESULTS: Group A showed a significantly increased percentage of forward motile sperm after the treatment (45.4% +/- 11.1%) as compared with pretreatment (28.6% +/- 9.2%) (P < 0.01), but no statistically significant differences were found in sperm density and the percentage of the sperm of normal morphology (P > 0.05). The rate of pregnancy was significantly higher in Group A (31.1%) than in B (3.8%) after the treatment (P < 0.01). No adverse events were found during the treatment. CONCLUSION:
L-carnitine, capable of significantly improving sperm motility and raising the rate of pregnancy, is a safe and effective therapeutic option for asthenozoospermia.
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Authors | Ya-xuan Wang, Shu-wen Yang, Chang-bao Qu, Hong-xu Huo, Wei Li, Jing-dong Li, Xue-liang Chang, Guang-zeng Cai |
Journal | Zhonghua nan ke xue = National journal of andrology
(Zhonghua Nan Ke Xue)
Vol. 16
Issue 5
Pg. 420-2
(May 2010)
ISSN: 1009-3591 [Print] China |
PMID | 20684322
(Publication Type: English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Asthenozoospermia
(drug therapy)
- Carnitine
(therapeutic use)
- Female
- Humans
- Male
- Pregnancy
- Pregnancy Rate
- Sperm Motility
(drug effects)
- Treatment Outcome
- Vitamin E
(therapeutic use)
- Young Adult
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