Abstract |
The aim of this study was to investigate epidermal growth factor receptor (EGFR) expression in feline cutaneous squamous cell carcinoma (FC-SCC) and assess its prognostic role. Nineteen formalin-fixed paraffin-embedded excisional biopsies of FC-SCC were tested for EGFR expression using immunohistochemistry (IHC). Relationships between EGFR expression and histopathological parameters (differentiation, mitotic activity), disease-free interval (DFI) and overall survival (OS) at 24 months were further investigated. Fourteen of 19 tumours (73.7%) were positive for EGFR, with great variation in intensity and proportion of labelled cells. EGFR expression was not correlated with tumour differentiation or mitotic activity. Nine cats (47.4%) died of tumour-related causes. Patients with EGFR-positive tumours had a significantly worse outcome (P=0.0217), with decreased DFIs (P=0.0075) and survival times (P=0.0391). These data suggest that EGFR expression carries a negative prognostic significance in FC-SCC. EGFR inhibitors in association with conventional treatments may improve outcome for the subgroup of cats with EGFR-positive tumours.
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Authors | Silvia Sabattini, Laura Marconato, Aurora Zoff, Maria Morini, Filippo Scarpa, Ombretta Capitani, Giuliano Bettini |
Journal | Journal of feline medicine and surgery
(J Feline Med Surg)
Vol. 12
Issue 10
Pg. 760-8
(Oct 2010)
ISSN: 1532-2750 [Electronic] England |
PMID | 20674427
(Publication Type: Journal Article)
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Copyright | Copyright © 2010 ISFM and AAFP. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- ErbB Receptors
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Topics |
- Animals
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Squamous Cell
(mortality, pathology, veterinary)
- Cat Diseases
(mortality, pathology)
- Cats
- ErbB Receptors
(metabolism)
- Female
- Immunohistochemistry
(veterinary)
- Male
- Prognosis
- Skin Neoplasms
(mortality, pathology, veterinary)
- Survival Analysis
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