IgM MGUS anti-MAG neuropathy with predominant muscle weakness and extensive muscle atrophy.

Abstract

We report a patient with anti-myelin-associated glycoprotein (MAG) neuropathy, predominantly exhibiting severe motor symptoms, accompanied by extensive muscle atrophy mimicking Charcot-Marie-Tooth disease. Nerve conduction studies revealed mild retardation of motor conduction velocities and significant prolongation of distal latency. Sural nerve biopsy revealed widely spaced myelin and positive staining of myelinated fibers with an IgM antibody. Predominant motor symptoms with muscle atrophy can be one of the clinical manifestations of anti-MAG neuropathy.

• Authors: Yuichi Kawagashira, Naohide Kondo, Naoki Atsuta, Masahiro Iijima, Haruki Koike, Masahisa Katsuno, Fumiaki Tanaka, Susumu Kusunoki, Gen Sobue
• Journal: Muscle & nerve (Muscle Nerve) Vol. 42 Issue 3 Pg. 433-5 (Sep 2010) ISSN: 1097-4598 [Electronic] United States
• PMID: 20665518 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulin M
• Immunoglobulins, Intravenous
• Myelin-Associated Glycoprotein

Topics

• Charcot-Marie-Tooth Disease (pathology)
• Diagnosis, Differential
• Electrodiagnosis
• Humans
• Immunoglobulin M (blood)
• Immunoglobulins, Intravenous (therapeutic use)
• Lower Extremity (pathology)
• Male
• Middle Aged
• Muscle Weakness (etiology, pathology, therapy)
• Muscle, Skeletal (pathology)
• Muscular Atrophy
• Myelin-Associated Glycoprotein (immunology)
• Neural Conduction (physiology)
• Paraproteinemias (pathology, therapy)