[Motor protein Kinesin-6 and ischemic heart disease].

Abstract

The review describes possible role of kinesins in development of coronary heart disease and efficacy of treatment with statins. Fourty five kinesins are represented in human body making up a superfamily of universal and simplest motor proteins which are expressed almost in all tissues. Level of kinesin 6 is 5% higher than expression of other kinesins in some segments of coronary arteries and it is relatively low in organs playing unknown role in susceptibility to atherosclerosis. As a result of several genoms wide association studies the role of polymorphic marker Thr719Arg of kinesin 6 gene in development of ischemic heart disease, myocardial infarction, and in efficacy of therapy with statins was revealed.

• Authors: O S Koroleva, D A Zateĭshchikov
• Journal: Kardiologiia (Kardiologiia) Vol. 50 Issue 6 Pg. 54-62 ( 2010) ISSN: 0022-9040 [Print] Russia (Federation)
• PMID: 20659029 (Publication Type: Journal Article, Review)

Chemical References

• Genetic Markers
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Molecular Motor Proteins
• KIF6 protein, human
• Kinesins

Topics

• Aged
• Alleles
• Animals
• Caenorhabditis elegans (genetics)
• Coronary Disease (blood, drug therapy, genetics)
• Coronary Vessels (metabolism, pathology)
• Drosophila melanogaster (genetics)
• Female
• Genetic Markers
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)
• Kinesins (chemistry, physiology)
• Lipid Metabolism (drug effects, genetics)
• Male
• Middle Aged
• Molecular Motor Proteins (physiology)
• Polymorphism, Genetic
• Risk Factors
• Saccharomyces cerevisiae (genetics)