Abstract | OBJECTIVE: DESIGN: A prospective study. SETTING: University hospital. PARTICIPANTS: A total of 61 patients (84% male) with a mean age of 70.39 ± 4.69 on a waiting list for CABG surgery were enrolled in the study. INTERVENTION: A complete neurocognitive evaluation was performed 1 day before surgery as well as 4 to 7 days and 1 month after surgery. During surgery, rSO(2) was monitored continuously. MEASUREMENTS AND MAIN RESULTS: POCD was defined as a reduction of 1 standard deviation on 2 or more neuropsychologic indices. Forty-six patients (80.7%) developed early POCD, and 23 (38.3%) showed late POCD. Patients whose rSO(2) decreased to less than 50% during the surgery experienced more POCD 4 to 7 days after surgery (p = 0.04). In addition, a decrease of more than 30% from the patient's baseline rSO(2) was associated with POCD 1 month after surgery (p = 0.03). CONCLUSION: Intraoperative cerebral oxygen desaturation is associated with early and late POCD in elderly patients. Cerebral oximetry is a promising tool in the prediction of subtle neuropsychologic deficits and further studies are needed.
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Authors | Emilie de Tournay-Jetté, Gilles Dupuis, Louis Bherer, Alain Deschamps, Raymond Cartier, André Denault |
Journal | Journal of cardiothoracic and vascular anesthesia
(J Cardiothorac Vasc Anesth)
Vol. 25
Issue 1
Pg. 95-104
(Feb 2011)
ISSN: 1532-8422 [Electronic] United States |
PMID | 20650659
(Publication Type: Journal Article)
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Copyright | Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved. |
Topics |
- Aged
- Algorithms
- Anesthesia, General
- Brain Chemistry
(physiology)
- Cognition Disorders
(psychology)
- Coronary Artery Bypass
(psychology)
- Educational Status
- Female
- Humans
- Male
- Mental Disorders
(complications)
- Neuropsychological Tests
- Oximetry
- Oxygen Consumption
(physiology)
- Postoperative Complications
(metabolism, psychology)
- Preanesthetic Medication
- Predictive Value of Tests
- Prospective Studies
- Spectroscopy, Near-Infrared
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