Abstract | BACKGROUND: METHODS: A 12-month randomized clinical trial compared a standard selective serotonin reuptake inhibitor treatment with (n = 27) or without ( n = 30) supplemental BDT in patients with OCD and concurrent MDD. Supplemental BDT was added during the first 16-week trial; all patients continued to be treated with only pharmacotherapy in the following continuation phase. The primary efficacy assessments were the Yale-Brown Obsessive Compulsive Scale and the 17-item Hamilton Rating Scale for Depression; the secondary efficacy measures included the Clinical Global Impression scale and the Global Assessment of Functioning. The data analysis was conducted on the 'intent-to-treat (ITT) efficacy patient sample'. RESULTS: Fifty patients completed the study. No difference between the 2 treatment groups was found at any point by any assessment method in the ITT study sample. CONCLUSIONS: Supplemental BDT in the treatment of patients with OCD with concurrent MDD who are receiving effective medication has no significant clinical effect on both obsessive and depressive symptoms.
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Authors | Giuseppe Maina, Gianluca Rosso, Sylvia Rigardetto, Simone Chiadò Piat, Filippo Bogetto |
Journal | Psychotherapy and psychosomatics
(Psychother Psychosom)
Vol. 79
Issue 5
Pg. 295-302
( 2010)
ISSN: 1423-0348 [Electronic] Switzerland |
PMID | 20616624
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright 2010 S. Karger AG, Basel. |
Chemical References |
- Serotonin Uptake Inhibitors
- Fluvoxamine
- Sertraline
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Topics |
- Adult
- Combined Modality Therapy
- Depressive Disorder, Major
(complications, drug therapy, therapy)
- Female
- Fluvoxamine
(administration & dosage, therapeutic use)
- Humans
- Male
- Obsessive-Compulsive Disorder
(complications, drug therapy, therapy)
- Psychiatric Status Rating Scales
- Psychotherapy, Brief
(methods)
- Selective Serotonin Reuptake Inhibitors
(administration & dosage, therapeutic use)
- Sertraline
(administration & dosage, therapeutic use)
- Treatment Outcome
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