Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects.

Abstract

We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBF(DCS)); and oxygen metabolism (rCMRO(2)). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF(ASL-MRI), n=12) cross-validate rCBF(DCS) against rCBF(ASL-MRI), showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.

• Authors: Turgut Durduran, Chao Zhou, Erin M Buckley, Meeri N Kim, Guoqiang Yu, Regine Choe, J William Gaynor, Thomas L Spray, Suzanne M Durning, Stefanie E Mason, Lisa M Montenegro, Susan C Nicolson, Robert A Zimmerman, Mary E Putt, Jiongjiong Wang, Joel H Greenberg, John A Detre, Arjun G Yodh, Daniel J Licht
• Journal: Journal of biomedical optics (J Biomed Opt) 2010 May-Jun Vol. 15 Issue 3 Pg. 037004 ISSN: 1560-2281 [Electronic] United States
• PMID: 20615033 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Hemoglobins
• Oxyhemoglobins
• Carbon Dioxide
• deoxyhemoglobin

Topics

• Carbon Dioxide (metabolism)
• Cerebral Cortex (blood supply)
• Heart Defects, Congenital (blood, physiopathology)
• Hemodynamics (physiology)
• Hemoglobins (metabolism)
• Humans
• Hypercapnia (physiopathology)
• Infant, Newborn
• Magnetic Resonance Imaging
• Optics and Photonics (methods)
• Oxyhemoglobins (metabolism)
• Regional Blood Flow (physiology)
• Spectroscopy, Near-Infrared (methods)
• Spectrum Analysis (methods)