Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis.

Abstract

OBJECTIVES:

We have reported that oral erythromycin (EM) inhibits periprosthetic tissue inflammation in a group of patients with aseptic loosening. The purpose of this study was to assess the efficacy of local, periprosthetic EM delivery in a rat model.

METHODS:

Uncoated Ti pins were press-fit into the right tibia of fourteen Sprague-Dawley rats following an intramedullar injection of UHMWPE (ultra high molecular weight polyethylene) particles. Revision surgeries were performed 2 months after the primary surgery. EM was applied to the Peri-Apatite™ (PA) layer of the titanium (Ti) pins. The previously implanted Ti pins were withdrawn and replaced with Ti pins coated either with (n = 7) or without (n = 7) EM. The rats were killed 1 month after "revision surgery". The EM efficacy was evaluated by (MicroCT) μCT and histology.

RESULTS:

μCT analysis showed that bone volume percentage (BV/TV) was significantly higher in the EM-treated group compared to the untreated group (p < 0.05). Histological analysis showed that EM treatment inhibits UHMWPE particle-induced periprosthetic tissue inflammation compared to the untreated group.

CONCLUSION:

This study demonstrated that periprosthetic EM delivery reduced periprosthetic inflammation and improved the quality of surrounding bone.

• Authors: Weiping Ren, Renwen Zhang, Monica Hawkins, Tong Shi, David C Markel
• Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (Inflamm Res) Vol. 59 Issue 12 Pg. 1091-7 (Dec 2010) ISSN: 1420-908X [Electronic] Switzerland
• PMID: 20607583 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Coated Materials, Biocompatible
• Polyethylenes
• ultra-high molecular weight polyethylene
• Erythromycin
• Titanium

Topics

• Animals
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Coated Materials, Biocompatible (metabolism)
• Erythromycin (administration & dosage, therapeutic use)
• Humans
• Implants, Experimental
• Inflammation (drug therapy, etiology, pathology)
• Osteolysis (drug therapy, etiology, pathology)
• Polyethylenes (metabolism)
• Prosthesis Failure
• Rats
• Rats, Sprague-Dawley
• Tibia (pathology)
• Titanium (metabolism)