Abstract | PURPOSE: The restriction of drug transporting across the blood-brain barrier (BBB) and the limit of drug penetrating into the tumor tissue remain the major obstacles for brain tumor chemotherapy. In the present study, we developed a functionalized liposomal nanoconstruct, epirubicin liposomes modified with tamoxifen (TAM) and transferrin (TF), for transporting drug across the BBB and afterwards targeting the brain glioma. METHODS: Evaluations were performed on the murine C6 glioma cells, the C6 glioma spheroids, the BBB model in vitro and the brain glioma-bearing rats. RESULTS: When compared with controls, epirubicin liposomes modified with TAM and TF showed the strongest inhibitory effect to C6 glioma cells or glioma spheroids in vitro, significant transport ability across the BBB model in vitro, an evident effect of targeting the brain tumor cells in vitro, and an extended median survival time in the brain glioma-bearing rats. CONCLUSION:
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Authors | Wei Tian, Xue Ying, Ju Du, Jia Guo, Ying Men, Yan Zhang, Ruo-Jing Li, Hong-Juan Yao, Jin-Ning Lou, Liang-Ren Zhang, Wan-Liang Lu |
Journal | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
(Eur J Pharm Sci)
Vol. 41
Issue 2
Pg. 232-43
(Oct 09 2010)
ISSN: 1879-0720 [Electronic] Netherlands |
PMID | 20600880
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Liposomes
- Epirubicin
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, pharmacokinetics, therapeutic use)
- Blood-Brain Barrier
- Brain Neoplasms
(drug therapy)
- Cell Line, Tumor
- Coculture Techniques
- Epirubicin
(administration & dosage, pharmacokinetics, therapeutic use)
- Glioma
(drug therapy)
- Liposomes
- Mice
- Rats
- Rats, Wistar
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