Abstract | BACKGROUND: METHODS: Following the donation of 400 ml of blood, 500 ml of hydroxyethyl starch solution was infused over 20 minutes into wakeful and desflurane-anesthetized volunteers. Blood was repeatedly sampled to measure hemoglobin concentration, a marker of plasma dilution, and fluid kinetic analysis was performed to evaluate changes in fluid space. RESULTS: Using a fluid kinetic model, we found that the mean volume of fluid space was 7,724 +/- 1,788 ml in wakeful volunteers and 6,818 +/- 4,221 ml in anesthetized volunteers, and the elimination rate constants were 7.1 +/- 3.5 ml/min and 19.4 +/- 4.6 ml/min, respectively. CONCLUSIONS: Infusion of colloid after mild hemorrhage resulted in similar expansions of plasma volume in desflurane-anesthetized and conscious individuals. During anesthesia, however, the expansion of plasma volume by colloid was decreased and of shorter duration than observed in conscious patients.
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Authors | Eun Ho Lee, Sun-Key Kim, Young Goo Yeo, Kyu Taek Choi |
Journal | Korean journal of anesthesiology
(Korean J Anesthesiol)
Vol. 58
Issue 6
Pg. 514-20
(Jun 2010)
ISSN: 2005-7563 [Electronic] Korea (South) |
PMID | 20589174
(Publication Type: Journal Article)
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