The effects of fenofibric acid alone and with statins on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia.

Abstract

OBJECTIVE:

To compare fenofibric acid (FA) + statin to respective monotherapies on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia.

RESEARCH DESIGN AND METHODS:

Post hoc analysis of over 2,000 metabolic syndrome patients administered either FA + low- or moderate-dose statin; FA alone; or low-, moderate-, or high-dose statin alone.

RESULTS:

FA + low- or moderate-dose statin combination therapy reduced the presence of metabolic syndrome (35.7 or 35.9%, respectively) more than low-, moderate-, or high-dose statin monotherapy (15.5, 16.6, or 13.8%, respectively), mostly due to improvements in triglycerides and HDL cholesterol levels. Mean glucose levels slightly decreased with FA monotherapy, slightly increased with statin monotherapy, and were essentially unchanged with FA + statin. FA with or without statin also reduced non-HDL cholesterol, apolipoprotein B, total cholesterol, VLDL cholesterol, and high-sensitivity C-reactive protein.

CONCLUSIONS:

FA + statin in patients with mixed dyslipidemia reduces the prevalence of metabolic syndrome.

• Authors: Harold E Bays, Eli M Roth, James M McKenney, Maureen T Kelly, Kamlesh M Thakker, Carolyn M Setze, Katie Obermeyer, Darryl J Sleep
• Journal: Diabetes care (Diabetes Care) Vol. 33 Issue 9 Pg. 2113-6 (Sep 2010) ISSN: 1935-5548 [Electronic] United States
• PMID: 20573750 (Publication Type: Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Hypolipidemic Agents
• Simvastatin
• fenofibric acid
• Fenofibrate

Topics

• Dyslipidemias (drug therapy, epidemiology)
• Fenofibrate (administration & dosage, analogs & derivatives, therapeutic use)
• Hypolipidemic Agents (administration & dosage, therapeutic use)
• Metabolic Syndrome (drug therapy, epidemiology)
• Simvastatin (administration & dosage, therapeutic use)