Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies.

Abstract	Invasive lobular carcinomas (ILC) of breast typically demonstrate intracytoplasmic mucin. We present a unique case of classical type ILC with abundant extracellular mucin and strong ERBB2 (HER2/neu) expression confirmed by immunohistochemistry and fluorescent in situ hybridization. Dual E-cadherin/p120 immunohistochemical stain demonstrated complete loss of membranous E-cadherin and the presence of diffuse cytoplasmic p120 staining, confirming the lobular phenotype. The tumor cells showed ductal-like cytoplasmic MUC1 staining, but were negative for MUC2 and other mucin gene markers. In addition, studies of tissue microarrays of 80 breast carcinomas with mucinous differentiation revealed 4 pure mucinous carcinomas showing significantly reduced E-cadherin staining without redistribution of p120 into cytoplasm. The findings suggest that the presence of extracellular mucin does not exclude a diagnosis of lobular carcinoma, and the morphologic and molecular characteristics of lobular and ductal carcinomas are more complex than previously appreciated.
Authors	Jing Yu, Rohit Bhargava, David J Dabbs
Journal	Diagnostic pathology (Diagn Pathol) Vol. 5 Pg. 36 (Jun 15 2010) ISSN: 1746-1596 [Electronic] England
PMID	20550696 (Publication Type: Case Reports, Journal Article)
Chemical References	Antigens, CD Biomarkers, Tumor CDH1 protein, human Cadherins Catenins MUC1 protein, human Mucin-1 ERBB2 protein, human Receptor, ErbB-2 Delta Catenin
Topics	Adenocarcinoma, Mucinous (chemistry, genetics, pathology, surgery) Aged Antigens, CD Biomarkers, Tumor (analysis, genetics) Biopsy Breast Neoplasms (chemistry, genetics, pathology, surgery) Cadherins (analysis) Carcinoma, Lobular (chemistry, genetics, pathology, surgery) Catenins (analysis) Female Humans Immunohistochemistry In Situ Hybridization, Fluorescence Mastectomy, Segmental Mucin-1 (analysis) Neoplasm Invasiveness Receptor, ErbB-2 (analysis, genetics) Tissue Array Analysis Up-Regulation Delta Catenin

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