Abstract | BACKGROUND: METHODS: The subjects included 125 pre-menopausal patients with breast cancer who were positive for hormone receptors and had undergone surgery at our institution. They were treated with four cycles of the CEF regimen and four cycles of docetaxel (Doc) before surgery as adjuvant chemotherapy. Thereafter, they were treated with an LH-RH agonist plus TAM for 24 months and followed to determine menstruation recovery. RESULTS: Menstruation resumed in 24 cases (19.2%) after the last LH-RH agonist treatment session. It took 7.3 ± 2.8 months for the patients to recover menstruation. The rate of menstruation recovery was 42.1% in patients aged 40 or younger and 9.2% in those aged 41 or older; the difference was significant. The period until menstruation recovery tended to be longer in older patients at the end of treatment. CONCLUSION: The menstruation recovery rate after therapy was higher in younger women. However, since ovarian function may be lost even in younger patients, the potential consequences of this therapy should be fully explained beforehand to patients who may wish to become pregnant.
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Authors | Kenichi Sakurai, Katsuhisa Enomoto, Sadao Amano |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 137
Issue 4
Pg. 615-20
(Apr 2011)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 20532911
(Publication Type: Journal Article)
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Chemical References |
- Cytarabine
- Tamoxifen
- Gonadotropin-Releasing Hormone
- Epirubicin
- Cyclophosphamide
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Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Breast Neoplasms
(drug therapy)
- Cyclophosphamide
(adverse effects)
- Cytarabine
(adverse effects)
- Epirubicin
(adverse effects)
- Female
- Gonadotropin-Releasing Hormone
(agonists)
- Humans
- Menstruation
(drug effects)
- Middle Aged
- Premenopause
- Tamoxifen
(adverse effects)
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