Levels and dynamic changes of serum fibroblast growth factor 23 in hypophosphatemic rickets/osteomalacia.

Abstract

BACKGROUND:

Hypophosphatemic rickets/osteomalacia is a group of diseases characterised by defective mineralization of bone due to hypophosphatemia and low 1,25-dihydroxy vitamin D. To explore the role of fibroblast growth factor 23 (FGF-23) in the regulation of phosphate homeostasis, we measured the circulating concentrations of this growth factor in healthy individuals and in patients with hypophosphatemic rickets/osteomalacia.

METHODS:

Nineteen patients with hypophosphatemic rickets/osteomalacia were included in hypophosphatemic group (HP, 12 female and 7 male, mean age was 30 years), and 19 healthy age-matched individuals served as the control group. Full length FGF-23 fragments were measured by two-site enzyme-linked immunosorbent assay.

RESULTS:

Mean FGF-23 concentrations were significantly higher in the HP group ((87.4 +/- 43.6) pg/ml) compared with the control group ((19.2 +/- 6.16) pg/ml; P < 0.001). In 1 patient with tumour-induced osteomalacia, serum FGF-23 concentrations were 84.1 pg/ml; these concentrations were normalized 2 hours after a hemangiopericytoma resection (7.8 pg/ml). Subsequently, serum 1,25(OH)(2) vitamin D3 concentrations significantly increased from 21.3 pg/ml to 89.3 pg/ml, and serum phosphorus levels were normalized.

CONCLUSIONS:

Serum FGF-23 concentrations were markedly elevated in patients with hypophosphatemic rickets. FGF-23 plays an important role in the pathogenesis of hypophosphatemic rickets/osteomalacia.

• Authors: Wei-bo Xia, Yan Jiang, Mei Li, Xiao-ping Xing, Ou Wang, Ying-ying Hu, Hua-bing Zhang, Huai-cheng Liu, Xun-wu Meng, Xue-ying Zhou
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 123 Issue 9 Pg. 1158-62 (May 05 2010) ISSN: 2542-5641 [Electronic] China
• PMID: 20529556 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• FGF23 protein, human
• Phosphates
• Fibroblast Growth Factors
• Fibroblast Growth Factor-23
• Calcitriol

Topics

• Adolescent
• Adult
• Calcitriol (blood)
• Child
• Child, Preschool
• Enzyme-Linked Immunosorbent Assay
• Familial Hypophosphatemic Rickets (blood)
• Female
• Fibroblast Growth Factor-23
• Fibroblast Growth Factors (blood)
• Humans
• Male
• Middle Aged
• Osteomalacia (blood)
• Phosphates (blood)
• Young Adult