Studies on the usefulness of intranasal inactivated influenza vaccines.

Abstract

Intranasal inactivated influenza vaccines have the advantage over parenteral vaccines in that they are not associated with the pain of an injection. However, they would be most useful if they were available for all age groups, including high-risk groups, and also would provide cross-protection against variant virus strains. Supporting the latter objective is our observation that intranasal inactivated vaccines provide cross-protection against variants within a subtype of the A virus (or variants within the B virus), together with inducing highly cross-reactive secretory-IgA antibodies to viral HA and the weakly cross-reactive IgG antibodies in the respiratory tract. This review summarizes the most important observations of our studies on intranasal inactivated influenza vaccines, which have been ongoing since 1987. These studies center on a mouse model of influenza in which mice are immunized intranasally with inactivated vaccines mixed with a cholera toxin B subunit adjuvant and then infected with mouse-adapted influenza viruses.

• Authors: Shin-ichi Tamura
• Journal: Vaccine (Vaccine) Vol. 28 Issue 38 Pg. 6393-7 (Aug 31 2010) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 20493820 (Publication Type: Journal Article, Review)
• Copyright: (c) 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Adjuvants, Immunologic
• Antibodies, Viral
• H1N1 virus hemagglutinin
• Hemagglutinin Glycoproteins, Influenza Virus
• Immunoglobulin A
• Immunoglobulin G
• Influenza Vaccines
• Vaccines, Inactivated

Topics

• Adjuvants, Immunologic (pharmacology)
• Administration, Intranasal
• Animals
• Antibodies, Viral (immunology)
• Cross Reactions
• Disease Models, Animal
• Hemagglutinin Glycoproteins, Influenza Virus (immunology)
• Immunity, Innate
• Immunoglobulin A (immunology)
• Immunoglobulin G (immunology)
• Influenza A Virus, H1N1 Subtype
• Influenza Vaccines (immunology)
• Mice
• Mice, Inbred BALB C
• Orthomyxoviridae Infections (immunology, prevention & control)
• Vaccines, Inactivated (immunology)