Abstract | PURPOSE: METHODS AND MATERIALS: A total of 32 patients who underwent positron emission and computed tomography (PET/CT) simulation were included; 18 patients had lung cancer, and 14 patients had pharyngeal cancer. For tumors of <or=2 cm, 2 to 5 cm, and >5 cm, thresholds were defined as 2.5 standardized uptake value (SUV), 35%, and 20% of the maximum FDG activity, respectively. The cervical and mediastinal lymph nodes with the shortest axial diameter of >or=10 mm were considered to be metastatic on CT (LNCT). The retropharyngeal lymph nodes with the shortest axial diameter of >or=5 mm on CT and MRI were also defined as metastatic. Lymph nodes showing maximum FDG activity greater than the adopted thresholds for radiation therapy planning were designated LNPET-RTP, and lymph nodes with a maximum FDG activity of >or=2.5 SUV were regarded as malignant and were designated LNPET-2.5 SUV. RESULTS: The sizes of gross tumor volumes on PET (GTVPET) with the adopted thresholds in the axial plane were visually well fitted to those of GTV on CT (GTVCT). However, the volumes of GTVPET were larger than those of GTVCT, with significant differences (p < 0.0001) for lung cancer, due to respiratory motion. For lung cancer, the numbers of LNCT, LNPET-RTP, and LNPET-2.5 SUV were 29, 28, and 34, respectively. For pharyngeal cancer, the numbers of LNCT, LNPET-RTP, and LNPET-2.5 SUV were 14, 9, and 15, respectively. CONCLUSIONS: Our multiple thresholds were applicable for delineating the primary target on PET/CT simulation. However, these thresholds were inaccurate for depicting malignant lymph nodes.
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Authors | Mitsuru Okubo, Yasumasa Nishimura, Kiyoshi Nakamatsu, Masahiko Okumura, Toru Shibata, Shuichi Kanamori, Kouhei Hanaoka, Makoto Hosono |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 77
Issue 2
Pg. 350-6
(Jun 01 2010)
ISSN: 1879-355X [Electronic] United States |
PMID | 20457349
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2010 Elsevier Inc. All rights reserved. |
Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Female
- Fluorodeoxyglucose F18
(pharmacokinetics)
- Humans
- Lung Neoplasms
(diagnostic imaging, pathology, radiotherapy)
- Lymph Nodes
(diagnostic imaging)
- Lymphatic Metastasis
(diagnostic imaging)
- Male
- Middle Aged
- Pharyngeal Neoplasms
(diagnostic imaging, pathology, radiotherapy)
- Positron-Emission Tomography
(methods)
- Radiopharmaceuticals
(pharmacokinetics)
- Radiotherapy Planning, Computer-Assisted
- Survival Rate
- Tomography, X-Ray Computed
(methods)
- Tumor Burden
- Young Adult
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