Abstract | INTRODUCTION: METHODS:
Cinacalcet 30 mg/day was prescribed to 17 renal transplant patients (6 women, 11 men) with a mean age of 49 years and hypercalcemia secondary to persistent hyperparathyroidism. The treatment started 58.17 ± 35.16 months posttransplant, with 1 year of follow-up. RESULTS:
Calcium in serum fell from 10.5 ± 0.74 to 9.4 ± 0.84 mg/dL (p<0.001), whereas phosphorous levels were not significantly altered. The fall in PTH was from 204.79 ± 78 to 148.55 ± 56 pg/mL (p<0.011). Kidney function remained stable, and immunosuppressant drug levels remained unchanged. The dose of cinacalcet was increased to 60 mg in 2 patients. No significant adverse effects were described, and none of the patients had to suspend the treatment. CONCLUSIONS:
Calcimimetic agents represent a therapeutic alternative in transplant patients with persistent hyperparathyroidism, as they correct hypercalcemia and reduce PTH levels with no adverse effects on kidney function. Prospective, controlled studies should be designed to evaluate the long-term effects and evolution after suspension of the treatment.
|
Authors | Rita Guerra, Ingrid Auyanet, Ernest J Fernández, Miguel Ángel Pérez, Elvira Bosch, Ana Ramírez, Santiago Suria, María Dolores Checa |
Journal | Journal of nephrology
(J Nephrol)
2011 Jan-Feb
Vol. 24
Issue 1
Pg. 78-82
ISSN: 1724-6059 [Electronic] Italy |
PMID | 20437396
(Publication Type: Journal Article)
|
Chemical References |
- Biomarkers
- Calcimimetic Agents
- Immunosuppressive Agents
- Naphthalenes
- PTH protein, human
- Parathyroid Hormone
- Phosphorus
- Creatinine
- Calcium
- Cinacalcet
|
Topics |
- Adult
- Aged
- Biomarkers
(blood)
- Calcimimetic Agents
(administration & dosage, adverse effects)
- Calcium
(blood)
- Cinacalcet
- Creatinine
(blood)
- Drug Administration Schedule
- Female
- Humans
- Hypercalcemia
(blood, drug therapy, etiology)
- Hyperparathyroidism
(blood, drug therapy, etiology)
- Immunosuppressive Agents
(therapeutic use)
- Kidney Transplantation
(adverse effects)
- Male
- Middle Aged
- Naphthalenes
(administration & dosage, adverse effects)
- Parathyroid Hormone
(blood)
- Phosphorus
(blood)
- Prospective Studies
- Spain
- Time Factors
- Treatment Outcome
|